Yale Clinical Neurosciences Imaging Center (CNIC)

Clinic Building

789 Howard Avenue,  6th floor 
New Haven, CT 06519 

Mental Imagery Study in Parkinson’s Disease

Study description:

Mental imagery refers to forming pictures in the mind and can have various forms such as visual imagery or motor imagery. It is a behavioral intervention that has been used successfully for numerous health promoting and performance enhancing purposes. In brain imaging studies, mental imagery has been shown to recruit virtually the same brain regions as the actual visual or motor tasks. This suggests that mental imagery has the potential to be used as a method for brain training. In this study, we investigate the effects of mental imagery combined with functional magnetic resonance imaging (MRI) on motor and cognitive performance and brain function in individuals with Parkinson’s disease.

MRI is a noninvasive imaging technique and does not include X-rays. It will allow us to observe how your brain activity changes in response to mental imagery training. We will also measure your motor function using various behavioral tests.


Study visits:

The study will consist of a total of 4 visits over a span of 6-8 weeks, each lasting between 1-3 hours in the morning. During these visits, you will be expected to do physical tasks (for example, walking, balancing, etc.), paper-pencil tests, and surveys. There will also be MRI scanning sessions for no longer than 1 hour to take images of your brain. In between visits, we will ask you to practice mental imagery at home for 15 min on a daily basis.

Location:

Visits will take place at the Yale Magnetic Resonance Research Center in The Anlyan Building located on 300 Cedar St, New Haven, CT, 06519

Screening:

Before we can enroll you into the study, we must go through your medical history and a MRI screening questionnaire for your own safety.

Dopamine Transporter Scan-Based Disease Progression Models for Early Parkinson’s Disease

Parkinson’s disease is a heterogeneous disorder and exhibits many subtypes with different rates of disease progression. This study aims to characterize disease progression in individuals with early Parkinson’s disease using machine-learning models on the PPMI DaTscan dataset.

MRI is a noninvasive imaging technique and does not include X-rays. It will allow us to observe how your brain activity changes in response to mental imagery training.

Measuring synaptic density in Parkinson’s disease with SV2A PET imaging

Synaptic changes play a critical role in the pathogenesis and progression of Parkinson’s disease.

This study investigates the changes in synaptic density in individuals with Parkinson’s disease using positron emission tomography (PET) imaging with 11C‑UCB‑J, a recently developed PET radiotracer that binds to the synaptic vesicle glycoprotein 2A

Structural and functional brain changes in Wilson’s Disease

Wilson’s disease is a genetic disorder that leads to copper accumulation in the body, particularly the brain and liver. The clinical manifestations are extremely diverse and can occur in the form of hepatic, neurologic, or psychiatric symptoms. There is still much that we do not understand about the disease, particularly from a neurologic perspective.

This study aims to characterize brain changes in individuals with Wilson’s disease using structural and functional MRI, and diffusion tensor imaging, and to correlate them with clinical and cognitive measures.